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Acura TLX vs Mercedes-Benz E-Class

2025 Acura TLX vs 2025 Mercedes-Benz E-Class — two rivals compared on efficiency, size, safety and reliability.

Acura TLX

2025 Acura TLX

Compact CarsAWD/4WD
VS0 – 5Mercedes-Benz E-Class wins 5 of 5 categories
Mercedes-Benz E-Class

2025 Mercedes-Benz E-Class

Midsize CarsAWD/4WDHybrid/EV

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The short version

The Mercedes-Benz E-Class is more fuel-efficient: 28 vs 25 MPG combined in its best version.

That works out to about $350 a year less in fuel for the Mercedes-Benz E-Class (EPA estimate, 15,000 miles).

Across all model years since 2005, the Mercedes-Benz E-Class has had fewer recall campaigns (0 vs 14).

The two cars

The 2025 Acura TLX is a compact car offered with 2 engines (2.0L 4-cyl turbo and 3.0L 6-cyl turbo) and front-wheel drive and all-wheel drive. It measures about 195 inches long and 75 inches wide on a 113-inch wheelbase, with a curb weight of roughly 3,999 lb (4dr Sedan).

The 2025 Mercedes-Benz E-Class is a midsize car offered with 2 engines (2.0L 4-cyl turbo and 3.0L 6-cyl turbo), including a hybrid version and rear-wheel drive and all-wheel drive. It measures about 195 inches long and 75 inches wide on a 117-inch wheelbase, with a curb weight of roughly 5,269 lb (Amg 4dr Sedan).

Buying used? The 2024 TLX and the 2024 E-Class have the fewest problems in our data; avoid the 2015 TLX.

Basics

Compact Cars
Class
Midsize Cars
Premium Gasoline
Fuel
Hybrid, Plug-in Hybrid
2.0L 4-cyl turbo, 3.0L 6-cyl turbo
Engines
2.0L 4-cyl turbo, 3.0L 6-cyl turbo
Front-Wheel Drive, All-Wheel Drive
Drivetrain
Rear-Wheel Drive, All-Wheel Drive

Efficiency

25 MPG
Best combined MPG
28 MPG
22 city
City / highway MPG (best)
25 city
$3,300
Fuel cost per year (EPA)
$2,950

Performance & space

355 hp
Horsepower (most powerful)
–
194.5 in
Length
194.9 in
75.2 in
Width
74 in
56.3 in
Height
57.9 in
3,999 lb
Curb weight (lightest)
4,189 lb

Safety & reliability

★★★★★
NHTSA overall rating
–
14
Driver-assist features standard
–
2
Recalls (2025)
0
14
Recalls, all years since 2005
0
4
Owner complaints (latest year)
0

Interest

8,272
Wikipedia views, 30 days
28,957

Buying used

2024
Best used year
2024
2015
Year to avoid
–

Green = clearly better. Prices are not included. How we calculate this →

Which one should you choose?

Choose the Acura TLX if…

It doesn't clearly beat the Mercedes-Benz E-Class on any measure we track.

Choose the Mercedes-Benz E-Class if…

  • You want lower fuel bills (28 vs 25 MPG)
  • You want a hybrid or electric option
  • You put reliability history first (0 vs 14 recalls since 2005)

Pros & cons of each

2025 Acura TLX

  • AWD / 4WD available
  • 5-star NHTSA safety ratingTop overall score in federal crash tests.
  • Lots of standard safety tech5 of 5 key driver aids standard on the versions we checked.
  • Below-average fuel economyBest version gets 25 MPG combined, 13% below the 2025 compact car average of 28.6 MPG.
  • Premium fuel requiredEvery gasoline version is rated for premium, which raises running costs.

2025 Mercedes-Benz E-Class

  • Hybrid version availableOffered as a hybrid and plug-in hybrid as well as gas.
  • AWD / 4WD available
  • No recalls so far
  • Premium fuel requiredEvery gasoline version is rated for premium, which raises running costs.

Full 2025 Acura TLX specs →Full 2025 Mercedes-Benz E-Class specs →Compare fuel costs for your driving →Compare size & garage fit →